Nobody, and I mean nobody, dies in my O.R.!
Dr. Barrett Cain

Dr. Barrett Cain is a neurosurgeon and Chief of Surgery at Chastain Park Memorial Hospital. He is portrayed by Morris Chestnut.


Dr. Barrett Cain is a neurosurgeon hired by Red Rock Medical to turn around Chastain’s finances and the third villain of the show.

Cain believes himself to be a superhuman physician, capable of curing crippling diseases. He’s charming when he wants to be, but his true personality is that of an utterly ruthless snake on quest for money and power. He has the ability to exact swift revenge on any who oppose him even if he is in the wrong. Cain does not truly care for his patients or any of his co-workers, he only cares that he can get large payout sums of money from the insurances of the former and that the latter obey him like a flock of sheep, only supporting his ways and not having a thought of their own.

Season Three

Despite his arrogance and ruthlessness, Cain is shown to not be a total monster. Cain privately admits to Ezra in "Support System" that as an intern, his inaction caused by doubting his instincts cost four patients their lives, but Red Rock and Ezra's mother, who was a mentor to Cain at the time, stepped in to save his job. In the present, after his patient Dawn Long is diagnosed with candida auris, Cain is insistent on coming forward due to the health risk, but Logan Kim threatens to expose Cain's mistakes as an intern if he does. Cain enlists Ezra's help to treat Sophia, an EMT who transported Dawn and got infected, behind Conrad's back. Conrad eventually figures it out on his own and Ezra reluctantly helps Cain cover it up, but Sophia dies. After Ezra reveals the truth, Conrad confronts a visibly-devastated and guilt-ridden Cain about his refusal to come forward and bowing to Red Rock, which cost someone their life as Conrad and Cain may have been able to save Sophia if he'd just told the truth. As Conrad leaves, Cain silently begins crying.

In "Burn It All Down," it's revealed that Cain is a former football player who was heading for the NFL before an ACL injury ended his career. The injury caused Cain to become bitter and angry and change, resulting in his girlfriend, Justine, breaking up with him. In the present, Justine arrives at the hospital in need of brain surgery and is reunited with Cain, who she admits regretting letting go of. At the same time, Cain admits to Nic that there are few people in his life who meant more to him than Justine did. However, Kit Voss' son-in-law, Derek, needs a neurosurgeon to help treat his candida auris infection, forcing Conrad and Bell to approach Cain for help. Cain decides to treat both Derek and Justine himself, but Derek develops complications while Justine suffers a seizure, forcing her into immediate surgery. After Cain fixes the problem with Bell's help, Bell orders him to go to Justine while Bell finishes the job on Derek. However, Justine dies, despite Cain's best desperate efforts, leaving him devastated. After the surgery, Cain sits in the OR with Justine's body. The next day, the superbug infestation comes out from an unknown source and Cain stands up to Kim, angry at the cover-up and blackmail he was forced to undergo. Kim subsequently approaches Conrad to be the new face of the hospital and implies that Cain's time at Chastain may be coming to an end.

Season Four

In "The Accidental Patient", Cain is hit by an ambulance while saving a woman's life and is severely injured. Cain is left in a coma following surgery with it being left unclear if he will ever wake up again.

In "Home Before Dark", Cain regains consciousness as Chastain is shutting down and starts fighting his ventilator, despite his inability to breathe on his own. Cain shows genuine concern for Nic's state, writing a message to Kit that he wants to help. After an elderly patient, Henry, gives Cain a figurine as a gift, Cain offers A.J. a radical solution to Henry's seemingly-hopeless condition, causing AJ to comment that "Cain may be down, but he's definitely not out." Cain's plan works and Henry's life is saved. However, Cain's condition results in him being transferred to the same crowded long-term care facility that Cain had sent his own patients to.

In "Hero Moments", Cain suddenly removes his vent after fighting it and is discovered to now be able to breathe on his own. Visiting Cain, Kit informs him that although his injuries from the accident have been treated, she doubts that he will ever regain more than 50% use of his right hand again and that it will takes weeks, possibly even months of physical therapy before Cain can even think about operating again. Cain dismisses Kit and asks to speak to the CEO of Chastain, only to learn that it's Kit herself.

Cain later talks with his lawyer about his still-pending lawsuit over the patient he lied to and caused to get COVID and complications as a result. Cain orders his lawyer to find out who the whistleblower at Chastain is for him.

In "First Days, Last Days", Cain, now using a cane to walk, is released from the care facility, returns to Chastain for his physical therapy, but doesn't do well. Cain clashes with Devon's sickle-cell patient Rose, admitting that without his surgical career, he doesn't know who he is. However, his continuing bad attitude leads Rose to snap back at him that he is being unrealistic about his career. Cain later has a meeting with Kit, who believes that with Cain's lack of success and bad attitude, he likely doesn't have a future at Chastain. Kit agrees to give Cain a little more time before making a final decision and Cain breaks down in the bathroom.

Returning home, Cain is confronted by AJ, who knows that Cain initiated an investigation into Mina after learning that she's the whistleblower, threatening both her career and visa. AJ threatens Cain to call it off, but when he tries to, Cain learns that it's too late and he can't stop what's been put into motion.


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